Wankowicz Lab Members
Stephanie Wankowicz, Ph.D.
she/her/hers
Principal Investigator
stephanie.wankowicz (@) vanderbilt.edu
https://stephaniewankowicz.github.io/
0000-0002-4225-7459 
stephanie-mullane-wankowicz-2657a726 
Stephanie's Citations 
@stephanie_mul 
stephaniewankowicz Stephanie earned her bachelor’s degree in Biochemistry and Molecular Biology from the University of Massachusetts, Amherst, where she researched the economics of the Clean Water Act under Dr. Paul Kolkoswki. After graduating, she worked as a Data Specialist at Dana-Farber Cancer Institute in the Lank Center for Genitourinary Oncology, managing the Bladder Cancer Translational Research Center under Joaquim Bellmunt. During this time, she performed clinical and translational research, helping to identify the relationship between the expression of PD-L1, an immune checkpoint marker, and overall survival in metastatic bladder cancer.
Subsequently, Stephanie worked as a computational biologist at the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard, working in Eli Van Allen’s lab. There, she developed algorithms utilizing high-throughput genomics data to assess responses to oncology treatments. She led the largest study of prostate cancer exomes, identifying new genes and pathways commonly mutated in prostate cancer. Additionally, she helped identify genetic biomarkers that predict patient responses to immunotherapy, targeted therapy, and chemotherapy.
In 2018, Stephanie began her graduate career in the Biophysics program at UCSF, working in James Fraser’s lab. She developed computational tools to automatically construct conformational ensembles from X-ray crystallography and cryo-EM data, extracting low-populated but biologically important states of macromolecules. Leveraging structural bioinformatics, she uncovered the spatial redistribution of entropy in ligand binding. Her graduate studies were supported by fellowships from NSF, UCSF Discovery Fellows Program, and the UCSF Antiviral Drug Discovery Program.
In 2024, Stephanie opened her lab at Vanderbilt University in the Molecular Physiology and Biophysics Department, Center for AI in Protein Dynamics, and Center for Structural Biology. The lab has two main areas of research: (1) improving the modeling of structural conformational ensembles from X-ray crystallography and cryo-EM data by leveraging generative AI, (2) elucidating the structural mechanisms by which conformational entropy influences binding specificity and catalysis. Find out more about our current research in the research tab.
Stephanie is deeply committed to enhancing equity and inclusion in science. At UCSF, she initiated a mentorship program for the Biophysics program at UCSF and founded a DEIJ Journal Club in the Fraser lab. She plans to continue these efforts at Vanderbilt.
Outside of the lab, you are most likely to find Stephanie running on the road or trail!
Adrian graduated from UCLA in 2024 with a degree in Biophysics. As an undergraduate, he conducted research at the Terasaki Institute under Dr. Yangzhi Zhu, focusing on wearable technology, and worked in Dr. Matteo Pellegrini’s lab applying machine learning to fungal phylogenetics. Adrian is particularly passionate about utilizing deep learning techniques to address fundamental questions in biophysics.
Outside of the lab, you can often find him rock climbing, looking for new camping spots, or enjoying live music.
Vratin has an undergraduate degree in Chemical Engineering and holds a Master’s degree in Computational Biology from Carnegie Mellon University, where he conducted research under Dr. David Koes. Vratin’s previous work focused on leveraging machine learning to improve protein binding pocket representation and dataset curation. He’s particularly passionate about applying data-driven methods to challenges in structural biology and biophysics.
When Vratin’s not laboring over bugs, you can find him playing the guitar or wandering about museums.